Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C

Smirnov V V<sup>*</sup>; Krasnykh L M; Shilovskii I P; Ryzhenkova A P; Khaitov M R; Drozdov V N

doi:10.1007/s11094-018-1802-9

登录

免费注册

赞收藏引用

科研之友

微信

新浪微博

Facebook

分享链接

Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C

作者：Smirnov V V^*; Krasnykh L M; Shilovskii I P; Ryzhenkova A P; Khaitov M R; Drozdov V N

来源：Pharmaceutical Chemistry Journal, 2018, 52(3): 254-256.

DOI：10.1007/s11094-018-1802-9

摘要

The composite Y14/siUTR, a complex consisting of cationic lipopeptide Y14 as an excipient and pharmaceutical substance of small interfering RNAtargeted against the UTR region of hepatitis C virus (siUTR), was investigated. The composite was intended to inhibit the hepatitis C virus replication cycle. The present work was aimed at developing pharmaceutical analytical methods for the components of this composite using HPLC-UV and UV spectroscopy.