Mast cells in vulnerable atherosclerotic plaques - a view to a kill

作者：Lindstedt Ken A^*; Mayranpaa Mikko I; Kovanen Petri T

来源：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2007, 11(4): 739-758.

DOI：10.1111/j.1582-4934.2007.00052.x

• apoptosis
• atherosclerosis
• endothelium
• erosion
• mast cell
• pericellular matrix
• plaque rupture
• proteases
• smooth muscle cell

The aim of the present review is to discuss the participation of mast cells in the pathogenesis of erosion and rupture of atherosclerotic plaques, the major causes behind acute coronary syndromes and myocardial infarction. We present ex vivo observations describing mast cells and their activation in human atherosclerotic plaques and discuss in vitro and in vivo data showing that mast cells are potential regulators of inflammation, immunity and adverse remodeling, including matrix remodeling and cell death. Furthermore, we focus on studies that have been performed with human tissues and human mast cells, but when appropriate, we also discuss observations made in animal models. Finally, we present potential pharmacological means to modulate mast cell responses in the arterial vessel walls.

• 出版日期2007-8