Multifunctional Magnetic Optical Sensor Particles with Tunable Sizes for Monitoring Metabolic Parameters and as a Basis for Nanotherapeutics

作者:Mistlberger Guenter*; Koren Klaus; Scheucher Elisabeth; Aigner Daniel; Borisov Sergey M; Zankel Armin; Poelt Peter; Klimant Ingo
来源:Advanced Functional Materials, 2010, 20(11): 1842-1851.
DOI:10.1002/adfm.201000321

摘要

Magnetic optical sensor particles with multifuncation cores and shells are synthesized via a facile nanoprecipitation method and the subsequent modification of the particle shell. The hydrophobic particle core includes optical oxygen indicators, a light harvesting system, photosensitizers, and magnetic nanoparticles. Further functionalities are ntroduced by modifying the shell with enzymes, antibodies, multiple layers of polyelectrolytes, stimuli-responsive polymers, and luminescent indicator dyes. The hydrodynamic diameter is tunable by varying different precipitation parameters.

  • 出版日期2010-6-9