ANEMIA IN PATIENTS WITH COINHERITED THALASSEMIA AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY

作者：Pornprasert Sakorn^*; Phanthong Siratcha

来源：Hemoglobin, 2013, 37(6): 536-543.

DOI：10.3109/03630269.2013.819558

• Anemia
• Hemoglobin (Hb)
• Hb A(2)/Hb E
• Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency
• Thalassemia

Thalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are genetic disorders that cause hemolytic anemia. In areas with high frequencies of both hematological disorders, coinheritance of G-6-PD deficiency with thalassemia can be found. Whether G-6-PD deficiency, coinherited with thalassemia, enhances severe anemia is still unclear. Hematological parameters between thalassemia carriers with G-6-PD deficiency and those without G-6-PD deficiency were compared. The G-6-PD deficiency was diagnosed in 410 blood samples from thalassemia patients using a fluorescent spot test. The levels of hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV) and Hb A(2)/Hb E [beta 26(B8) Glu -%26gt; Lys; HBB: c. 79G%26gt;A] were measured using an automated blood counter and high performance liquid chromatography (HPLC), respectively. The G-6-PD deficiency was found in 37 samples (9.02%). Mean levels of Hb, PCV, MCV and Hb A(2)/E were similar between the two groups. Thus, G-6-PD deficiency did not enhance red blood cell pathology or induce more anemic severity in thalassemia patients.

• 出版日期2013