Understanding the role of NRF2-regulated miRNAs in human malignancies

作者：Shah Niraj M; Rushworth Stuart A; Murray Megan Y; Bowles Kristian M; MacEwan David J^*

来源：Oncotarget, 2013, 4(8): 1130-1142.

DOI：10.18632/oncotarget.1181

• NRF2
• miRNA
• transcription factor
• oncogenesis
• drug resistance

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a key transcription factor that regulates the expression of over a hundred cytoprotective and antioxidant genes that provide cellular protection from reactive oxygen species. Chemotherapy resistance in several cancers has been linked to dysregulation of the NRF2 signalling pathway, moreover there is growing evidence that NRF2 may contribute to tumorigenesis. MicroRNA (miRNA) are small non-coding RNA sequences that post-transcriptionally regulate mRNA sequences. In cancer pathogenesis, aberrantly expressed miRNAs can act as either tumor suppressor or oncogenic miRNA. Recent evidence has been described that identifies a number of miRNA that can be regulated by NRF2. This review outlines the importance of NRF2 in regulating miRNA, and the functional role this may have in the tumorigenesis of human malignancies and their chemotherapy resistance.

• 出版日期2013-8