Development of the crosslinking reactions to RNA triggered by oxidation

作者：Kusano Shuhei; Haruyama Takuya; Ishiyama Shogo; Hagihara Shinya; Nagatsugi Fumi^*

来源：Chemical Communications, 2014, 50(30): 3951-3954.

DOI：10.1039/c3cc49463b

A novel crosslink-forming nucleobase, 2-amino-6-(1-ethylthiovinyl)-purine (ATVP), which is triggered by the oxidation of sulfide to sulfoxide, has been developed. The oxidation of ATVP within the duplex proceeded with H2O2 and FeCl2. We have successfully developed the crosslinking reactions activated by oxidation.

• 出版日期2014