alpha-Tocopherol succinate enhances pterostilbene anti-tumor activity in human breast cancer cells in vivo and in vitro

作者：Tam Ka Wai; Ho Chi Tang; Tu Shih Hsin; Lee Wen Jui; Huang Ching Shui; Chen Ching Shyang; Wu Chih Hsiung; Lee Chia Hwa^*; Ho Yuan Soon^*

来源：Oncotarget, 2018, 9(4): 4593-4606.

DOI：10.18632/oncotarget.23390

• vitamin E
• tocopherol-associated protein
• alpha-tocopheryl succinate
• pterostilbene
• breast cancer

Vitamin E (Vit. E) is considered an essential dietary nutrient for humans and animals. An enormous body of evidence indicates the biological and protective effects of Vit. E consumption. Tocopherol-associated protein (TAP) is a major tocopherol-binding protein affecting Vit. E stimulation and downstream signaling transduction. However, how Vit. E utilizes TAP as an anti-cancer mechanism remains unclear. Microarray analysis of signature gene profiles in breast cancer cells treated with alpha-tocopheryl succinate (alpha-TOS, a Vit. E isoform) resulted in cell cycle arrest and anticancer activity in breast cancer cells. Pterostilbene (PS), a natural dietary antioxidant found in blueberries, in combination with alpha-TOS synergistically maximized breast cancer cell growth inhibition by disrupting signal transduction, transcription factors and cell cycle proteins. In a xenograft mouse model, PS treatment with Vit. E inhibited breast tumor growth and cell invasion, which were evaluated using our recently developed circulating tumor cell (CTC) detection assay. Because dietary Vit. E and PS supplementation contributed to preventative and therapeutic effects in vitro and in vivo, this combination may benefit breast cancer therapy in the clinic.

• 出版日期2018-1-12
• 单位rutgers