Stereoselective intermolecular [2+2]-photocycloaddition reactions of maleic anhydride: stereocontrolled and regiocontrolled access to 1,2,3-trifunctionalized cyclobutanes

作者：Hernvann Florian; Rasore Gloria; Declerck Valerie; Aitken David J^*

来源：Organic and Biomolecular Chemistry, 2014, 12(41): 8212-8222.

DOI：10.1039/c4ob01383b

Short synthetic sequences commencing with the photosensitized [2 + 2]-cycloaddition reactions of maleic anhydride with either allyl alcohol or propargyl alcohol have been elaborated to provide access to 1,2,3-trisubstituted cyclobutanes with three differentiated one-carbon substituents and complementary stereochemical patterns. These intermediates were used to prepare three discrete stereo-and regioisomers of hydroxymethylated cyclobutane beta-amino acids in orthogonally protected form.

• 出版日期2014