Direct Phosphorus-Induced Fluoroalkylthiolation with Fluoroalkylsulfonyl Chlorides

作者：Jiang, Lvqi; Yi, Wenbin^*; Liu, Qiran

来源：Advanced Synthesis & Catalysis, 2016, 358(23): 3700-3705.

DOI：10.1002/adsc.201600651

• electron-rich arenes and thiols
• fluoroalkylsulfonyl chlorides
• fluoroalkylthiolation
• phosphorus-induced reaction

A simple and practical method of fluoroalkylthiolation using fluoroalkylsulfonyl chlorides (RfSO2Cl, R-f=CF3, C4F9, C8F17, CF2H and CH2CF3) has been developed. These easy-to-handle reagents are powerful and can be used for electrophilic fluoroalkylthiolation of electron-rich arenes and thiols using diethyl phosphite as reducing agent.

• 出版日期2016-12
• 单位南京理工大学