Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia

作者：Schuster Friedhelm R^*; Meisel Roland; Fuehrer Monika; Reuther Susanne; Hauer Julia; Tischer Johanna; Feuchtinger Tobias; Laws Hans Juergen; Kolb Hans Jochem; Borkhardt Arndt

来源：British Journal of Haematology, 2013, 162(6): 802-807.

DOI：10.1111/bjh.12455

• haploidentical transplantation
• acute refractory leukaemia
• graft-versus-leukaemia-effect
• CD6-depletion

The treatment outcome of children with refractory acute leukaemia or relapse post-stem cell transplantation is dismal. We report 10 children (non-remission n=7) who underwent a new haploidentical transplant approach utilizing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells. Nine patients had successful engraftment and no evidence of leukaemia. Acute and chronic graft-versus-host-disease was observed in five and three patients, respectively; two patients died of treatment-related toxicity. Seven patients relapsed after 7 (range 3-34) months, however two patients are alive at 65 and 70years. This approach provides anti-leukaemic activity even in heavily pre-treated children but long-term disease control requires further intervention.

• 出版日期2013-9