A general and mild copper-catalyzed three-component synthesis of protected homoallyl amines

作者：Pasunooti Kalyan Kumar; Leow Min Li; Vedachalam Seenuvasan; Gorityala Bala Kishan; Liu Xue Wei^*

来源：Tetrahedron Letters, 2009, 50(24): 2979-2981.

DOI：10.1016/j.tetlet.2009.04.008

A mild and highly efficient copper-catalyzed, one-pot, three-component reaction is developed for the synthesis of homoallyl amines. Reaction of an aldehyde, a carbamate, and allyltrimethylsilane in the presence of 5 mol % Cu(OTf)(2) furnishes the corresponding protected homoallylic amines in good to excellent yields.

• 出版日期2009-6-17
• 单位南阳理工学院