An improved synthesis of 6-o-methyl-scutellarein through selective benzylation

作者:Zhang, Wei; Dong, Ze-Xi; Gu, Ting; Li, Nian-Guang*; Wu, Wen-Yu; Zhang, Peng-Xuan; Tang, Yu-Ping; Yang, Jian-Ping; Xue, Xin; Fang, Fang; Li, He-Min; Cheng, Hai-Bo; Duan, Jin-Ao; Shi, Zhi-Hao
来源:Journal of Chemical Research, 2015, 39(11): 674-676.
DOI:10.3184/174751915X14452625043383

摘要

An improved synthesis of 6-O-methyl-scutellarein is described. Benzyl bromide was selected to protect both the hydroxyl groups at C-4' and C-7 in scutellarein. The product was then methylated and deprotected to produce the target compound in high yield in four steps.