Aminomethylation of Aryl Halides Using alpha-Silylamines Enabled by Ni/Photoredox Dual Catalysis

作者：Remeur Camille; Kelly Christopher B; Patel Niki R; Molander Gary A

来源：ACS Catalysis, 2017, 7(9): 6065-6069.

DOI：10.1021/acscatal.7b01973

• aminomethylation
• radicals
• nickel/photoredox dual catalysis
• visible light
• cross-coupling

A protocol for the aminomethylation of aryl halides using alpha-silylamines via Ni/photoredox dual catalysis is described. The low oxidation potential of these silylated species enables facile single electron transfer (SET) oxidation of the amine followed by rapid desilylation. The resulting alpha-amino radicals can be directly funneled into a nickel-mediated cross-coupling cycle with aryl halides. The process accomplishes aminomethylation under remarkably mild conditions and tolerates numerous aryl- and heteroaryl halides with an array of functional groups.

• 出版日期2017-9