Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination

作者:Noguchi Masanori*; Mine Takashi; Komatsu Nobukazu; Suekane Shigetaka; Moriya Fukuko; Matsuoka Kei; Yutani Shigeru; Shichijo Shigeki; Yamada Akira; Toh Uhi; Kawano Kouichiro; Azuma Kouichi; Uemura Hirotsugu; Okuno Kiyotaka; Matsumoto Kazumasa; Yanagimoto Hiroaki; Yamanaka Ryuya; Oka Masaaki; Todo Satoru; Sasada Tetsuro; Itoh Kyogo
来源:Cancer Biology and Therapy, 2010, 10(12): 1266-1279.
DOI:10.4161/cbt.10.12.13448

摘要

To investigate immunological biomarkers to predict overall survival of advanced cancer patients under treatment with personalized peptide vaccination, correlations between overall survival and biomarkers, including cytotoxic T lymphocyte (CTL) and immunoglobulin G (IgG) responses to the vaccinated peptides, were investigated in 500 advanced cancer patients who received a personalized peptide vaccination from October 2000-October 2008. The best clinical response was assessed for in 436 patients, 43 patients (10%) had partial response, 144 patients (33%) had stable disease and 249 patients (57%) had progressive, with a median overall survival of 9.9 months. Both lymphocyte counts prior to the vaccination (p = 0.0095) and increased IgG response (p = 0.0116) to the vaccinated peptides, along with performance status (p < 0.0001), well correlated with overall survival. To confirm the superiority of IgG response to CTL response, the samples from advanced castration-resistant prostate cancer patients who survived more than 900 days (n = 20) and those who died within 300 days (n = 23) were analyzed further. As a result, both the numbers of peptides, to which increased IgG responses were observed, and the fold increases in IgG levels were significantly higher in long-term survivors (p = 0.000282 and p = 0.00045). In contrast, CTL responses were not statistically different between the two groups. Both lymphocyte numbers and IgG response were thus suggested to be biomarkers of cancer vaccine for advanced cancer patients.

  • 出版日期2010-12-15