Analyzing the efficacy of frequent sodium checks during hypertonic saline infusion after elective brain tumor surgery

作者：Tucker Alexander M; Lee Seung J; Chung Lawrance K; Barnette Natalie E; Voth Brittany L; Lagman Carlito; Nagasawa Daniel T; Yang Isaac^*

来源：Clinical Neurology and Neurosurgery, 2017, 156: 24-28.

DOI：10.1016/j.clineuro.2017.02.011

Objective: To assess the utility of frequent sodium checks (every 6 h) in patients receiving hypertonic saline (HS) after elective brain tumor surgeries.
Patients and methods: A single-institution retrospective review of patients having undergone elective craniotomies for brain tumors and treated with postoperative continuous intravenous infusions of 3% HS was performed. Changes in serum sodium values were analyzed at different time points. The rates of <12.5, 25, and 50 cc/h infusions were also examined. Healthcare cost analysis was performed by extrapolating our cohort to the total number of craniotomies performed in the United States.
Results: No significant differences among sodium values checked between 0 to 4, 4-6, 6-8, 8-10, and >10h were observed (P=.64). In addition, no differences in serum sodium values among the rates of <12.5, 25, and 50 cc/h were found (P=.30). No patients developed symptoms of acute hypernatremia.
Conclusions: Serum sodium values did not significantly change more than 10 h after infusion of HS. Further studies are needed to determine the optimal frequency of routine sodium checks to increase the quality of care and decrease healthcare costs.

• 出版日期2017-5