Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles

作者：Borrmann Ruediger; Knop Nils; Rueping Magnus

来源：Chemistry - A European Journal, 2017, 23(4): 798-801.

DOI：10.1002/chem.201605450

<jats:title>Abstract</jats:title><jats:p>An enantioselective synthesis of spirocyclic indoline scaffolds was achieved by applying an asymmetric iridium‐catalyzed hydrogenation of 3<jats:italic>H</jats:italic>‐indoles. Low catalyst loadings and mild reaction conditions provide a broad range of differently substituted products with excellent yields and enantioselectivities. The developed methodology allows an efficient synthesis of this important spirocyclic structural motif, which is present in numerous biologically active molecules and privileged structures in medicinal chemistry.</jats:p>

• 出版日期2017-1