High Sensitivity Cardiac Troponin T and Cognitive Function in the Oldest Old: The Leiden 85-Plus Study

作者：Bertens Anne Suzanne^*; Sabayan Behnam; de Craen Anton J M; Van der Mast Roos C; Gussekloo Jacobijn

来源：Journal of Alzheimer's Disease, 2017, 60(1): 235-242.

DOI：10.3233/JAD-170171

• Cardiac disease
• cognitive function
• high sensitivity cardiac troponin T
• oldest old

Background: Impaired cardiac function has been related to accelerated cognitive decline in late-life.
Objective: To investigate whether higher levels of high sensitivity cardiac troponin T (hs-cTnT), a sensitive marker for myocardial injury, are associated with worse cognitive function in the oldest old.
Methods: In 455 participants of the population-based Leiden 85-plus Study, hs-cTnT was measured at 86 years. Cognitive function was measured annually during four years with the Mini-Mental State Examination (MMSE).
Results: Participants in the highest gender-specific tertile of hs-cTnT had a 2.0-point lower baseline MMSE score than participants in the lowest tertile (95% confidence interval (CI) (95% CI 0.73-3.3), and had a 0.58-point steeper annual decline in MMSE during follow-up (95% CI 0.06-1.1). The associations remained after adjusting for sociodemographic and cardiovascular risk factors excluding those without a history of overt cardiac disease.
Conclusion: In a population-based sample of the oldest old, higher levels of hs-cTnT were associated with worse cognitive function and faster cognitive decline, independently from cardiovascular risk factors and a history of overt cardiac disease.

• 出版日期2017
• 单位西北大学