Anti-melanogenesis properties of quercetin- and its derivative-rich extract from Allium cepa

作者：Arung Enos Tangke; Furuta Shoko; Ishikawa Hiroya; Kusuma Irawan Wijaya; Shimizu Kuniyoshi^*; Kondo Ryuichiro

来源：Food Chemistry, 2011, 124(3): 1024-1028.

DOI：10.1016/j.foodchem.2010.07.067

• Allium cepa
• Red onion
• Quercetin derivatives
• Anti-melanogenesis
• Antioxidant

In an effort to find a new whitening agent, we have found that the methanol extract of the dried skin of Allium cepa showed inhibition of melanin formation. Bioassay-guided fractionation led to the isolation of quercetin (1) and quercetin 4'-O-beta-glucoside (3) from A. cepa as the inhibitors of melanin formation in B16 melanoma cells with IC(50) values of 26.5 and 131 mu M, respectively. In addition, we evaluated the effect of some quercetin derivatives, such as isoquercitrin (2), quercetin 3,4'-O-diglucoside (4), rutin (5) and hyperin (6) on B16 melanoma cells. These quercetin derivatives did not show any inhibition of melanin formation. Furthermore, the ORAC values of compounds 1-6 were 7.64, 8.65, 4.82, 4.32, 8.17 and 9.34 mu mol trolox equivalents/mu mol. respectively. Dried skin of red onion showed inhibitory activity against melanin formation in B16 melanoma cells, as well as antioxidant properties.

• 出版日期2011-2-1