Aqueous extracts from dietary supplements influence the production of inflammatory cytokines in immortalized and primary T lymphocytes

作者：Hanlon Paul R^*; Robbins Melissa G; Scholl Chris; Barnes David M

来源：BMC Complementary and Alternative Medicine, 2009, 9(1): 51.

DOI：10.1186/1472-6882-9-51

Background: Congaplex (R) and Immuplex (R) are dietary supplements that have been traditionally used to support immune system function. The purpose of these experiments was to determine whether Congaplex (R) and Immuplex (R) affect immune function using primary and immortalized T lymphocytes.
Methods: Immortalized CEM and Jurkat T lymphocytes and primary peripheral mononuclear blood cells (PBMCs) were treated with the aqueous extracts from Congaplex (R) and Immuplex (R) to determine the effects of these products on cytokine production in activated T lymphocytes.
Results: Congaplex (R) enhanced phytohemagglutinin/phorbol 12-myristate 13-acetate (PHA/PMA) stimulation of both CEM and Jurkat cells as measured by the production of cytokines, while Immuplex (R) suppressed PHA/PMA-induced production of cytokines, with the exception of interleukin (IL)-8 which was enhanced by Immuplex (R). In vitro treatment of PBMCs from 10 healthy donors with Congaplex (R) or Immuplex (R) decreased PHA-stimulated production of interferon (IFN). but increased the production of IL-13.
Conclusions: While the effects of Congaplex (R) and Immuplex (R) differed in these two models, these data demonstrate that the aqueous extracts from these two dietary supplements can affect the inflammatory response of T lymphocytes.

• 出版日期2009-12-14