Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

作者：Smith Amos B III^*; Kim Won Suk

来源：Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(17): 6787-6792.

DOI：10.1073/pnas.1015265108

• benzyne cycloaddition
• natural product-like macrolides

In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring "natural product-like" macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.

• 出版日期2011-4-26