Acoustic injury in mice: 129/SvEv is exceptionally resistant to noise-induced hearing loss

作者：Yoshida N; Hequembourg SJ; Atencio CA; Rosowski JJ; Liberman MC^*

来源：Hearing Research, 2000, 141(1-2): 97-106.

DOI：10.1016/S0378-5955(99)00210-5

• cochlea
• age-related hearing loss
• noise-induced hearing loss

129/SvEv is an inbred mouse strain popular for use in genetic knockout studies. Here, we compare normal auditory function and vulnerability to acoustic injury in wild-type mice of the 129/SvEv vs. CBA/CaJ strains. Compound action potentials (CAPs) and distortion product otoacoustic emissions (DPOAEs) showed slightly higher thresholds for 129/SvEv re CBA/CaJ, especially at frequencies > 20 kHz. Middle-ear motion (i.e. umbo velocity) was similar in the two strains; although frequencies > 20 kHz could not be evaluated. Permanent threshold shift (PTS) and hair cell losses, measured 1 week after high-intensity exposure to an 8-16 kHz noise band, were smaller in 129/SvEv at all exposure levels and durations from 97 dB SPL x 2 h to 106 dB SPL x 8 h. Furthermore, PTS growth with increasing exposure energy was slower in 129/SvEv(< 2 dB/dB) than CBA/CaJ (9 dB/dB). These data suggest that the vulnerability differences lie in the inner ear, not the middle ear. Several 129/Sv substrains show age-related hearing loss (AHL): 129/SvEv has not yet been evaluated (Zheng, Q.Y., Johnson, K.R., Erway, L.C., 1999. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear. Res. 130, 94-107). Thus, although other strains with AHL, e.g. C57Bl/6J, show increased vulnerability to noise-induced hearing loss (NIHL), pairing of AHL and NIHL vulnerabilities may not be obligatory.

• 出版日期2000-3