Antioxidant Principles of Tanacetum vulgare L. Aerial Parts

作者：Juan Badaturuge Malindra; Habtemariam Solomon^*; Jackson Caroline; Thomas Michael J K

来源：Natural Product Communications, 2009, 4(11): 1561-1564.

DOI：10.1177/1934578x0900401121

• Tanacetum vulgare
• Asteraceae
• 3,5-O-dicaffeoylquinic acid
• axillarin
• luteolin
• antioxidant

The methanolic extract of aerial parts of Tanacetum vulgare L. (Asteraceae) and its fractions were investigated for antioxidant activity. The crude extract displayed DPPH radical scavenging effects with an EC(50) value of 37 +/- 1.2 mu g/mL (n=3). Activity-guided fractionations of the crude extract resulted in the isolation of three antioxidant compounds; 3,5-O-dicaffeoylquinic acid (3,5-DCQA), axillarin and luteolin. 3,5-DCQA was the major constituent with antioxidant activity (IC(50) = 9.7 mu M) comparable with that of the standard quercetin (IC(50) = 8.8 mu M). Though the isolated compounds were previously known for their antioxidant effects, this is the first report on the identification of 3,5-DCQA from Tanacetum vulgare. The displayed potent antioxidant activity of the crude extract and isolated active principles is in support of the traditional medicinal uses of the Plant for disease conditions such as wound healing, rheumatic arthritis and other inflammatory conditions.

• 出版日期2009-11