Novel production and characterization of porous calcium phosphate suitable for bone tissue engineering applications

作者：Stergioudi F; Choleridis A; Paulidou E; Smymaios E; Michailidis N^*

来源：Ceramics International, 2015, 41(3): 3822-3832.

DOI：10.1016/j.ceramint.2014.11.058

• Sintering
• Mechanical properties
• Apatite
• Biomedical applications

Porous calcium phosphate materials have found enormous use in biomedical applications including hard tissue regeneration. In this study, tailored made open-cell porous calcium phosphate samples were produced by employing a novel dissolution sintering process, using crystalline raw cane sugar as a leachable pore former material. The process parameters of the production stages were properly adjusted to optimise the quality and structure of open-cell porous calcium phosphatesamples. The influence of sintering conditions on the macro and micro-structure of the resultant porous product is investigated with a view to produce high-quality and strong porous calcium phosphate samples. Preliminary in-vitro biodegradation results indicate formation of a bone-like apatite on the porous samples surface. Mechanical performance of the produced porous calcium phosphate samples is interesting and dictates their potential use as low load-bearing implants for hard tissue replacement or as filling materials and scaffolds for cancellous bone defects repairs.

• 出版日期2015-4