Are Baseline High Molecular Weight Adiponectin Levels Associated with Radiographic Progression in Rheumatoid Arthritis and Osteoarthritis?

作者：Klein Wieringa Inge R; Andersen Stefan N; Herb van Toorn Linda; Kwekkeboom Joanneke C; van der Helm van Mil Anette H M; Meulenbelt Ingrid; Huizinga Tom W J; Kloppenburg Margreet; Toes Rene E M; Ioan Facsinay Andreea^*

来源：Journal of Rheumatology, 2014, 41(5): 853-857.

DOI：10.3899/jrheum.130888

• RADIOGRAPHIC PROGRESSION
• TOTAL ADIPONECTIN
• HAND OSTEOARTHRITIS
• HIGH MOLECULAR WEIGHT ADIPONECTIN
• RHEUMATOID ARTHRITIS

Objective. To investigate whether high molecular weight adiponectin (hmwAPN) mediates the associations of total adiponectin (totAPN) with radiographic progression in rheumatoid arthritis (RA) and hand osteoarthritis (HOA).
Methods. Associations between baseline hmwAPN or totAPN levels with radiographic progression were determined using multivariate linear regression or generalized estimated equations.
Results. In patients with RA, totAPN associated positively, whereas in patients with HOA it associated negatively with radiographic progression. In contrast, hmwAPN did not associate significantly with radiographic progression in either cohort.
Conclusion. Our data indicate that the differential effects associated between totAPN and radiographic progression in either RA or HOA are not mediated by hmwAPN.

• 出版日期2014-5