A Cu(II)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-a]pyridines

作者：Liu, Yun^*; Wang, Wenhui; Han, Junwen; Sun, Jinwei^*

来源：Organic and Biomolecular Chemistry, 2017, 15(44): 9311-9318.

DOI：10.1039/c7ob02014g

• ONE-POT SYNTHESIS
• DEPENDENT KINASE INHIBITORS
• COPPER-CATALYZED SYNTHESIS
• ANTIVIRAL ACTIVITY
• ROOM-TEMPERATURE
• SELECTIVE CLASS
• C-NUCLEOSIDES
• AGENTS
• AMINATION
• DISCOVERY

A copper-promoted cascade decarboxylative halogenation and oxidative diamination reaction sequence of 2-aminopyridines with alkynoic acids has been developed for the synthesis of 2-haloimidazo[1,2-a]pyridines. In this reaction, two C-N bonds and one C-halogen bond are formed in one pot, generating the desired products in good yields. This is the first report on the synthesis of 2-haloimidazo[1,2-a]pyridine derivatives from alkynoic acids.

• 出版日期2017-11-28
• 单位南京信息工程大学