A structure parameter for porous pharmaceutical tablets obtained with the aid of Wiener bounds for effective permittivity and terahertz time-delay measurement

作者：Bawuah Prince; Chakraborty Mousumi; Ervasti Tuomas; Zeitler J Axel; Ketolainen Jarkko; Gane Patrick A C; Peiponen Kai Erik

来源：International Journal of Pharmaceutics, 2016, 506(1-2): 87-92.

DOI：10.1016/j.ijpharm.2016.04.026

• Pharmaceutical tablet
• Microcrystalline cellulose
• Indomethacin
• Terahertz
• Microstructures
• Effective medium

A structure parameter that can be used to predict the pattern of arrangement of porous inclusions in pharmaceutical tablets is introduced. By utilizing the effective refractive index of a pharmaceutical tablet obtained from terahertz time-domain measurements, we have shown that there exists a promising correlation between the calculated structural parameter and the porosity of training sets of pharmaceutical tablets, having well-defined characterization. Knowing of the structural arrangement, i.e. combined constituent skeletal-pore elements in series, parallel or mixed within porous media, could serve as a basis for understanding the ingress and permeation of liquids in such media. In the realm of pharmaceutical applications, such knowledge of the structural arrangement of air voids within a medicinal tablet could enable correlation with mechanical strength and dissolution behaviour in aqueous systems.

• 出版日期2016-6-15