Damage of atmospheric fine particles on DNA in alveolar macrophages of rats

作者：Meng Zi Qiang; Zhang Quan Xi

来源：China Environmental Science, 2005, 25(1): 15-17.

Damage from atmospheric fine particles (PM2.5) in isolated DNA of alveolar macrophages of rats in Taiyuan City was studied applying single cell gel electrophoresis technique. Under the toxic condition of PM2.5 with concentrations of 0, 75, 150, 300, 450 μg/mL respectively, after toxicosis of 1 h, tail lengths of nuclear DNA in the alveolar macrophages from rats were 2.82, 6.76, 10.25, 14.47, 23.87 μm respectively; after toxicosis of 4 h, the tail lengths were 2.80, 18.15, 32.90, 43.22, 55.51 μm respectively; after toxicosis of 10 h, the tail lengths were 2.49, 26.57, 39.73, 52.10, 70.09 μm respectively. This showed that PM2.5 could induce the DNA damage in alveolar and aggravate with increase of particle concentration and prolongation of toxicosis time, emerging dearly the dosage-effect and time-effect relations.

• 出版日期2005