A nano-fibrous assembly of collagen-hyaluronic acid for controlling cell-adhesive properties

作者:Fujie Toshinori; Furutate Sho; Niwa Daisuke; Takeoka Shinji*
来源:Soft Matter, 2010, 6(19): 4672-4676.
DOI:10.1039/c0sm00527d

摘要

We report an artificially fabricated extracellular matrix (ECM)-like nanostructure, which utilizes self-assembly of collagen and hyaluronic acid in a quasi two-dimensional space of tens-of-nm thickness, displaying different cellular adhesive characteristics depending on the structural properties between the fibril and non-fibril elements. This nano-fibrous assembly will facilitate a mechanobiological approach for the development of tissue-engineering scaffolds.

  • 出版日期2010