Administering of pregabalin and acetaminophen on management of postoperative pain in patients with nasal polyposis undergoing functional endoscopic sinus surgery

作者：Rezaeian Ahmad^*

来源：Acta Oto-Laryngologica, 2017, 137(12): 1249-1252.

DOI：10.1080/00016489.2017.1358464

• Nasal polyposis
• functional endoscopic sinus surgery
• postoperative pain
• pregabalin
• acetaminophen

Background: Management of postoperative pain is a common problem in endoscopic sinus surgery. The objective of this study is the evaluation of pregabalin and acetaminophen effects on the management of postoperative pain in patients with nasal polyposis undergoing functional endoscopic sinus surgery (FESS).
Materials and methods: In this clinical trial, double-blinded study, 70 patients with nasal polyposis who have indication of FESS were enrolled to this study. After operation, patients were divided randomly into pregabalin and acetaminophen therapy groups. The pregabalin group (n=35) was treated under pregabalin 50mg TDS and the acetaminophen group (n=35) was treated under tablet acetaminophen 500 mg/6h. Each group was administered for 3 d. The visual analogue scale (VAS) was measured in onset, 12, 24, 48 and 72h after surgery. All data were entered into SPSS software (SPSS Inc., Chicago, IL) and appropriate statistical tests were assessed to every relation.
Results: In this study, there was no significant difference between two groups according to VAS in onset (p=.37); however, VAS in 12, 24, 48 and 72h after operation was significantly lower in the pregabalin group compared with the acetaminophen group (p<.0001, for every four). Also in the pregabalin group, adverse effects were significantly lower than the acetaminophen group (p<.03).
Conclusions: Pregabalin has more effect, safely and usefully than acetaminophen on the management of postoperative pain in the patients with nasal polyposis undergoing functional endoscopic sinus surgery.

• 出版日期2017