科研之友
微信
新浪微博
Facebook
分享链接
摘要
Objective: To clarify whether maternal HBsAg positivity may add risk for adverse neonatal outcomes and even affect child's growth. @@@ Methods: The perinatal data and neonatal outcomes in 380 HBsAg-positive and 428 HBsAg-negative women delivered during 2002-2004 were investigated. Furthermore, 271 (71.3%) children of HBsAg-positive and 297 (69.4%) of HBsAg-negative mothers were followed at ages of 5-7 years. Child's growth including weight, height, and health conditions were evaluated. @@@ Results: The prevalence of preterm birth was relatively higher in HBsAg-positive group (2.9% versus 1.4%), but it failed to reach statistical significance (p = 0.140). There was no difference in other neonatal outcomes including stillbirth (0.5% versus 0.2%), neonatal death (0.5% versus 0.5%) and congenital malformation (0.8% versus 1.4%). Logistic regression analyses demonstrated maternal HBsAg positivity had no adverse influence on neonatal outcomes. Abnormal health conditions, other than adverse neonatal outcomes, was identified in one child (0.3%) of HBsAg-positive mother and four children (0.9%) of HBsAg-negative mothers at follow-up (p = 0.444). No maternal death occurred in HBsAg-positive or -negative mothers. @@@ Conclusions: Maternal HBsAg carrier status does not add risk for adverse neonatal outcomes or child's growth; therefore, heightening surveillance for adverse neonatal complications in HBV-infected pregnant women may be unnecessary.
