A matter of time - How transient transcription factor interactions create dynamic gene regulatory networks

作者：Swift Joseph; Coruzzi Gloria M

来源：Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 2017, 1860(1): 75-83.

DOI：10.1016/j.bbagrm.2016.08.007

• Transcription factor
• Transcription dynamics
• Transient DNA binding
• Plant genomics
• Epigenetics

Dynamic reprogramming of transcriptional networks enables cells to adapt to a changing environment. Thus, it is crucial not only to understand what gene targets are regulated by a transcription factor (TF) but also when. This review explores the way TFs function with respect to time, paying particular attention to discoveries made in plants - where coordinated, genome-wide responses to environmental change is crucial to the survival of these sessile organisms. We investigate the molecular mechanisms that mediate transient TF-DNA binding, and assess how these rapid and dynamic interactions translate to long-term temporal regulation of genomes. We also discuss how current molecular techniques can catch, and sometimes miss, transient TF-target interactions that underlie dynamic cellular responses. This article is part of a Special Issue entitled: Plant Gene Regulatory Mechanisms and Networks, edited by Dr. Erich Grotewold and Dr. Nathan Springer.

• 出版日期2017-1