A key genetic factor for fucosyllactose utilization affects infant gut microbiota development

作者：Matsuki Takahiro^*; Yahagi Kana; Mori Hiroshi; Matsumoto Hoshitaka; Hara Taeko; Tajima Saya; Ogawa Eishin; Kodama Hiroko; Yamamoto Kazuya; Yamada Takuji; Matsumoto Satoshi; Kurokawa Ken

来源：Nature Communications, 2016, 7(1): 11939.

DOI：10.1038/ncomms11939

Recent studies have demonstrated that gut microbiota development influences infants' health and subsequent host physiology. However, the factors shaping the development of the microbiota remain poorly understood, and the mechanisms through which these factors affect gut metabolite profiles have not been extensively investigated. Here we analyse gut microbiota development of 27 infants during the first month of life. We find three distinct clusters that transition towards Bifidobacteriaceae-dominant microbiota. We observe considerable differences in human milk oligosaccharide utilization among infant bifidobacteria. Colonization of fucosyllactose (FL)-utilizing bifidobacteria is associated with altered metabolite profiles and microbiota compositions, which have been previously shown to affect infant health. Genome analysis of infants' bifidobacteria reveals an ABC transporter as a key genetic factor for FL utilization. Thus, the ability of bifidobacteria to utilize FL and the presence of FL in breast milk may affect the development of the gut microbiota in infants, and might ultimately have therapeutic implications.

• 出版日期2016-6