Maternal vitamin and iron supplementation and risk of infant leukaemia: a report from the Children's Oncology Group

作者：Linabery A M; Puumala S E; Hilden J M; Davies S M; Heerema N A; Roesler M A; Ross J A^*

来源：British Journal of Cancer, 2010, 103(11): 1724-1728.

DOI：10.1038/sj.bjc.6605957

• epidemiology
• infants
• vitamin
• leukaemia

BACKGROUND: Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia.
METHODS: Mothers of 443 cases of infant leukaemia diagnosed during 1996-2006 and 324 frequency-matched controls completed interviews. Associations were evaluated by unconditional logistic regression.
RESULTS: We observed no associations between prenatal vitamin (odds ratio (OR) = 0.79, 95% confidence interval (CI): 0.44-1.42) or iron supplementation (OR = 1.07, 95% CI: 0.75-1.52) and infant leukaemia after adjustment for race/ethnicity and income. Similar results were observed for leukaemia subtypes analysed separately.
CONCLUSION: The observed null associations may be attributable to high supplementation rates and/or national fortification programmes. British Journal of Cancer (2010) 103, 1724-1728. doi:10.1038/sj.bjc.6605957 www.bjcancer.

• 出版日期2010-11-23