A Novel Method for Tinidazole Detection Using Mn-Modified CdSe/CdS Quantum Dots as a Luminescent Probe

作者：Wu, Yanzi; Lin, Yan; Wei, Fangdi; Hu, Miao; Liu, Liping; Zhou, Ping; Hu, Qin^*

来源：Journal of Nanoscience and Nanotechnology, 2014, 14(5): 3976-3982.

DOI：10.1166/jnn.2014.8656

• Tinidazole
• QDs
• Luminescent Probe

A new method for the determination of tinidazole based on the fluorescence quenching of citrate-capped Mn-modified CdSe/CdS quantum dots was developed. In aqueous solution, the fluorescence of the quantum dots at 610 nm was quenched gradually with the increase of the concentration of tinidazole. Based on this, a simple, fast, low-cost and specific quantitative method for tinidazole detection was set up. Under optimal conditions, a good linearity was built between the fluorescence quenching of Mn-modified CdSe/CdS quantum dots and the concentration of tinidazole in the range of 4 similar to 400 mu M with a correlation coefficient of 0.9998. The limit of detection (3 sigma/K) was 0.4 mu M. The proposed method was applied to the detections of tinidazole in tablets and injections with satisfactory results.

• 出版日期2014-5
• 单位南京医科大学