Naphthoquinone-like Polyketide Isolated from Streptomyces sp RI-77 and Its Predicted Biosynthetic Pathway

作者：Izumikawa Miho; Satou Ryutaro; Motohashi Keiichiro; Nagai Aya; Ohnishi Yasuo; Takagi Motoki^*; Shin ya Kazuo

来源：Journal of Natural Products, 2011, 74(12): 2588-2591.

DOI：10.1021/np200651e

A novel naphthoquinone-like polyketide, JBIR-85 (1), with a unique skeleton and antioxidative activity was isolated from a culture of Streptomyces sp. RI-77. The planar structure of 1 was established on the basis of extensive NMR and MS analyses. The structure of 1 including the absolute configuration was established via X-ray crystallographic analysis. Since 1 exhibits a unique skeleton, we performed feeding experiments to reconfirm the structure and predict the biosynthetic pathway.

• 出版日期2011-12