Adipose tissues as endocrine target organs

作者：Lanthier Nicolas; Leclercq Isabelle A^*

来源：Best Practice & Research in Clinical Gastroenterology, 2014, 28(4): 545-558.

DOI：10.1016/j.bpg.2014.07.002

• Visceral adipose tissue
• Adipose tissue macrophage
• Subcutaneous adipose tissue
• Brown adipose tissue
• Beige adipose tissue
• Insulin
• Obesity
• Metabolic syndrome
• Diabetes

In the context of obesity, white adipocyte hypertrophy and adipose tissue macrophage infiltration result in the production of pro-inflammatory adipocytokines inducing insulin resistance locally but also in distant organs and contributing to low grade inflammatory status associated with the metabolic syndrome. Visceral adipose tissue is believed to play a prominent role. Brown and beige adipose tissues are capable of energy dissipation, but also of cytokine production and their role in dysmetabolic syndrome is emerging. This review focuses on metabolic and inflammatory changes in these adipose depots and contribution to metabolic syndrome. Also we will review surgical and pharmacological procedures to target adiposity as therapeutic interventions to treat obesity-associated disorders.

• 出版日期2014-8