An efficient synthesis of the C27-C45 fragment of lagunamide A, a cyclodepsipeptide with potent cytotoxic and antimalarial properties

作者：Liu Hui Ming; Chang Chieh Yu; Lai Ya Chi; Yang Mei Due; Chang Ching Yao

来源：Tetrahedron: Asymmetry , 2014, 25(2): 187-192.

DOI：10.1016/j.tetasy.2013.11.020

An efficient and stereoselective synthesis of the entire C27-C45 moiety of lagunamide A has been achieved from 1-[(4S)-4-benzyl-2-thioxothiazolidin-3-yl]propan-1-one in six steps with 22% overall yield. The key step in the synthesis is an asymmetric acetal aldol reaction featuring the enantioselective addition of a chiral thiazolidinethione-derived titanium enolate to an acetal to establish the stereochemistry at C39.

• 出版日期2014-1-31
• 单位中国医科大学