Aging Is Not Associated With Bone Marrow-Resident Progenitor Cell Depletion

作者：Povsic Thomas J^*; Zhou Jiying; Adams Stacie D; Bolognesi Michael P; Attarian David E; Peterson Eric D

来源：Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2010, 65(10): 1042-1050.

DOI：10.1093/gerona/glq110

• Bone marrow
• Progenitor cell
• Endothelial progenitor cells
• Aging
• Circulating progenitor cell

Changes in progenitor cell biology remain at the forefront of many theories of biologic aging, but there are limited studies evaluating this in humans. Aging has been associated with a progressive depletion of circulating progenitor cells, but age-related bone marrow-resident progenitor cell depletion has not been systematically determined in humans. Patients undergoing total hip replacement were consented, and bone marrow and peripheral progenitor cells were enumerated based on aldehyde dehydrogenase activity and CD34 and CD133 expression. Circulating progenitors demonstrated an age-dependent decline. In contrast, marrow-resident progenitor cell content demonstrated no age association with any progenitor cell subtype. In humans, aging is associated with depletion of circulating, but not marrow-resident, progenitors. This finding has impact on the mechanism(s) responsible for age-related changes in circulating stem cells and important implications for the use of autologous marrow for the treatment of age-related diseases.

• 出版日期2010-10