Assembling and releasing performance of supramolecular hydrogels formed from simple drug molecule as the hydrogelator

作者：Wang Yu Jiang; Yan Liang; Tang Li Ming^*; Yu Ran

来源：Chinese Chemical Letters, 2007, 18(8): 1009-1012.

DOI：10.1016/j.cclet.2007.05.008

• supramolecular hydrogel
• hydrogelator
• releasing

A simple drug compound, 4-oxo-4-(2-pyridinylamino) butanoic acid (defined as AP), was able to gel water at 4 wt% concentration under various conditions. In the superstructure, AP molecules assembled into fibrous aggregates driving by hydrogen bonds and pi-pi stacking interaction. The gels with different backbone structures released drug molecules in different speeds. (0 2007 Li Ming Tang. Published by Elsevier B.V. on behalf of Chinese Chemical Society.

• 出版日期2007-8
• 单位清华大学