Modified drug release of poloxamer matrix by including water-soluble and water-insoluble polymer

作者：Gonzalez Y M; Ghaly E S^*

来源：Drug Development and Industrial Pharmacy, 2010, 36(1): 64-71.

DOI：10.3109/03639040903061363

• Poloxamer 407
• theophylline swellable matrix
• carbopol
• hydroxypropyl methylcellulose
• sustained release

Background: The ability of poloxamer 407 to control drug release was investigated along with the effect of incorporation of a second polymer with poloxamer on dissolution behavior. Methods: Tablets made of 30% w/w/ theophylline and 15%, 25%, 50%, or 69% poloxamer were prepared. Additionally, tablets containing mixture of poloxamer with carbomer or hypromellose in a 1:1 ratio and at different total levels (15%, 30%, and 50%) were also tested. Results: Data show that as the level of poloxamer increased, drug release decreased. Formulations containing poloxamer: hypromellose 1:1 at 50% level and formulations containing poloxamer: carbomer 1:1 at 30% level produced controlled release matrices over 24 hours of testing dissolution. The mechanism of drug release follows anomalous relaxation non-Fickian diffusion model. Conclusions: These results suggest that the combination of poloxamer 407 with hypromellose or carbomer is feasible and has potential to offer the formulator control over drug release.

• 出版日期2010