A Common Building Block for the Syntheses of Amorfrutin and Cajaninstilbene Acid Libraries toward Efficient Binding with Peroxisome Proliferator-Activated Receptors

作者：Aidhen Indrapal S^*; Mukkamala Ramesh; Weidner Christopher; Sauer Sascha

来源：Organic Letters, 2015, 17(2): 194-197.

DOI：10.1021/ol503135u

A common building block for the synthesis of amorfrutin and cajaninstilbene acid derivatives has been developed. The library of synthesized compounds has enabled identification of new nontoxic ligands of peroxisome proliferator-activated receptors (PPAR) and potential inhibitors of the transcriptional corepressor protein NCoR. The biological data holds promise in identification of new potential leads for the antidiabetic drug discovery process.

• 出版日期2015-1-16