A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei

作者：Waag DM^*; McCluskie MJ; Zhang NL; Krieg AM

来源：Infection and Immunity, 2006, 74(3): 1944-1948.

DOI：10.1128/IAI.74.3.1944-1948.2006

Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.

• 出版日期2006-3