Impact of prophylactic central neck dissection on oncologic outcomes of papillary thyroid carcinoma: a review

作者：Mamelle Elisabeth; Borget Isabelle; Leboulleux Sophie; Mirghani Haithem; Suarez Carlos; Pellitteri Phillip K; Shaha Ashok R; Hamoir Marc; Robbins K Thomas; Khafif Avi; Rodrigo Juan P; Silver Carl E; Rinaldo Alessandra; Ferlito Alfio^*; Hartl Dana M

来源：European Archives of Oto-Rhino-Laryngology, 2015, 272(7): 1577-1586.

DOI：10.1007/s00405-014-3104-5

• Lymph node metastasis
• Prophylactic neck dissection
• Papillary thyroid carcinoma
• Recurrence-free survival
• Radioactive iodine

Prophylactic neck dissection (PND) for papillary thyroid carcinoma (PTC) is controversial. Our aim was to assess current levels of evidence (LE) according to the Oxford Centre for Evidence-based Medicine (http://www.cebm.net/?O=1025) regarding the oncologic benefits of PND. Data were analyzed via MEDLINE keywords: PTC, differentiated thyroid carcinoma, PND, central lymph node metastases, central compartment, recurrence-free survival. There was conflicting evidence regarding the rate of reoperation for recurrence, with some studies showing a lower rate after PND with increased recurrence-free survival and a higher rate of undetectable pre- and post-ablation thyroglobulin levels (LE 4), whereas other studies did not show a difference (LE 4). Only one study (LE 4) showed improved disease-specific survival with PND. PND may improve recurrence-free survival, although this is supported by only a low LE. Current recommendations can only be based on low-level evidence.

• 出版日期2015-7