Using Ion-Molecule Reactions To Overcome Spectral Interferences in ICP-MS: A Guided Inquiry Approach for Upper-Level Undergraduate and Graduate Students

作者：Newman Karla^*

来源：Journal of Chemical Education, 2018, 95(7): 1211-1215.

DOI：10.1021/acs.jchemed.8b00026

• Upper-Division Undergraduate
• Graduate Education/Research
• Analytical Chemistry
• Physical Chemistry
• Hands-On Learning/Manipulatives
• Inquiry-Based/Discovery Learning
• Atomic Spectroscopy
• Instrumental Methods
• Mass Spectrometry

Almost all commercial quadrupole ICP-MS instruments use collision/reaction cells to either attenuate spectral interferences or shift the analyte of interest to an interference-free m/z (e.g., by O addition). A laboratory practical was developed to introduce the students to the basic operating principles of ICP-MS using a hands-on approach, with an emphasis on practical strategies for the effective use of reaction cells in ICP-MS. Vanadium, and the ClO+ diatomic interference formed in HCl matrixes, was used as an illustrative example, which enabled students to explore charge transfer, clustering, condensation, and oxygen atom addition reactions of a single analyte, and evaluate the most effective approach for the chemical resolution of V+ and ClO+ ions. This laboratory practical provided graduate students with a basic skill set to support the effective use of ICP-MS with reaction cell technology in their research projects.

• 出版日期2018-7