N,N '-Dioxide-Cu(OTf)(2) Complex Catalyzed Highly Enantioselective Amination Reaction of N-Acetyl Enamide

作者：Chang Lu; Kuang Yulong; Qin Bo; Zhou Xin; Liu Xiaohua; Lin Lili; Feng Xiaoming^*

来源：Organic Letters, 2010, 12(10): 2214-2217.

DOI：10.1021/ol100540p

The N,N'-dioxide-Cu(OTf)(2) complexes were applied in,the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.

• 出版日期2010-5-21
• 单位四川大学