Donor race and outcomes in kidney transplant recipients

作者：Molnar Miklos Z; Kovesdy Csaba P; Bunnapradist Suphamai; Streja Elani; Krishnan Mahesh; Mucsi Istvan; Norris Keith C; Kalantar Zadeh Kamyar^*

来源：Clinical Transplantation, 2013, 27(1): 37-51.

DOI：10.1111/j.1399-0012.2012.01686.x

• cardiovascular death
• delayed graft function
• donor race
• ethnicity
• graft failure
• kidney transplantation
• malnutrition-inflammation complex
• mortality

Background African Americans are at greater risk to reach end-stage renal disease and this risk may carry over in a kidney transplant recipient after kidney transplantation. Methods Linking the five-yr patient data of a large dialysis organization to the Scientific Registry of Transplant Recipients, we identified 13 692 hemodialysis patients who underwent first kidney transplantation. Mortality or graft failure and delayed graft function risks were estimated by Cox%26apos;s regression (hazard ratio [HR] and 95% confidence interval) and logistic regression, respectively. Results Patients were 48 +/- 14 yr old and included 39% women and 26% patients with diabetes. After adjusting for several relevant clinical and transplant-related variables, African American donor race was associated with higher all-cause mortality, with HR of 1.39 (1.09-1.78) for all-cause mortality, 1.80 (1.17-2.76) for cardiovascular mortality, 1.30 (1.03-1.64) for death-censored graft loss and 1.31 (1.10-1.57) for combined outcome over the six-yr observation period. In the non-African American recipient subcohort, but not in the African American recipient subcohort, African American donor race was associated with higher risk of death-censored graft loss (2.24 [1.44-3.49]) in our fully adjusted model. Conclusions African American donor race was associated with increased all-cause and cardiovascular mortality and graft loss.

• 出版日期2013-2