Mitochondrial-targeted fluorescent probes for reactive oxygen species

作者：Dickinson Bryan C; Srikun Duangkhae; Chang Christopher J^*

来源：Current Opinion in Chemical Biology, 2010, 14(1): 50-56.

DOI：10.1016/j.cbpa.2009.10.014

As the primary consumers of oxygen within all aerobic organisms, mitochondria are a major source of cellular reactive oxygen species (ROS) derived from the in vivo chemistry of oxygen metabolism. Mitochondrial ROS have been traditionally implicated in aging and in a variety of pathologies, including cancer, neurodegeneration, and diabetes, but recent studies also link controlled mitochondrial ROS fluxes to cell regulation and signaling events. Progress in the development of mitochondrial-targeted fluorescent small-molecule indicators that detect specific ROS with high selectivity offers a promising approach for interrogating mitochondrial ROS production, trafficking, and downstream biological effects.

• 出版日期2010-2