ARF6: a newly appreciated player in G protein-coupled receptor desensitization

作者：Hunzicker Dunn M^*; Gurevich VV; Casanova JE; Mukherjee S

来源：FEBS Letters, 2002, 521(1-3): 3-8.

DOI：10.1016/S0014-5793(02)02822-3

• ADP ribosylation factor 6
• ADP ribosylation factor nucleotide binding site opener
• Arrestin
• G protein-coupled receptor

The luteinizing hormone/choriogonadotropin hormone receptor (LH/CG R) signals to regulate ovulation, corpus luteum formation, and fetal survival during pregnancy. Agonist binding to the LH/CG R is poorly reversible, emphasizing the importance of a cellular mechanism to temper signaling by a potentially persistently active receptor. Like other G protein-coupled receptors (GPCRs), signaling by this receptor is modulated by its binding of an arrestin. We have identified ADP ribosylation factor 6 (ARF6) as a protein whose activation state is regulated by the LH/CG R and which functions to regulate the availability of plasma membrane-docked arrestin 2 to this receptor. We hypothesize that ARF6 might also serve GPCRs other than the LH/CG R to regulate the availability of arrestin 2 for receptor desensitization.

• 出版日期2002-6-19
• 单位西北大学