Assessing sequence and relationship of regional maturation in corpus callosum and internal capsule in preterm and term newborns by diffusion-tensor imaging

作者：Miao XiaoLin; Qi Min; Cui ShuDong^*; Guan YaFei; Jia ZhenYu; Hong XunNing; Jiang YanNi

来源：International Journal of Developmental Neuroscience, 2014, 34(1): 42-47.

DOI：10.1016/j.ijdevneu.2014.01.004

• White matter maturation
• FA
• ADC
• Brain development

Background: Diffusion-tensor imaging (DTI) can be used to investigate water diffusion in living tissue. Objective: To investigate sequence and relationship of regional maturation in corpus callosum (CC) and internal capsule (IC) in preterm and term.
Methods: DTI was performed on 11 preterm infants at less than 37 weeks of corrected gestational age (group I), 21 preterm infants at equivalent-term (group II), 11 term infants during neonatal period (group III). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in: anterior limb of IC (ALIC), posterior limb of IC (PLIC), genu and splenium of CC.
Results: FA in splenium was more than that in other regions except genu of group I. Differences of FA between genu and PLIC were significant only in group III. ADC in genu was more than that in other regions but in splenium of groups land II. Differences of ADC between splenium and ALIC were insignificant except group II. Higher FA and lower ADC in PLIC were gotten compared with those in ALIC. Correlations of FA and of ADC existed in CC and IC.
Conclusion: Maturation sequence was splenium followed by genu, then by PLIC and last by ALIC in term at neonatal period. Genu's maturation in preterm at equivalent-term was hindered. Regional maturation's correlations existed in CC and IC.

• 出版日期2014-5
• 单位南京医科大学