科研之友
微信
新浪微博
Facebook
分享链接
摘要
Previous studies indicated that the RECQL5 gene polymorphism was associated with human cancers. However, the association of RECQL5 gene polymorphism with breast cancer remains unclear. In the present study, we investigated the association between polymorphisms of the RECQL gene and breast cancer in a Chinese population. We selected four polymorphisms of the RECQL5 gene (rs820186, rs820196, rs820200, and rs4789223) for the present study. The genotyping was performed using the TaqMan method in 510 patients with breast cancer and 510 age- and sex-matched non-cancer controls. We found that rs820196 and rs828200 polymorphisms of RECQL5 were associated with breast cancer. For rs820196, the CC genotype (16.7 vs 9.4 %, P<0.001) and C allele (42.5 vs 34.3 %, P<0.001) were common in the breast cancer patients than in the control subjects, respectively. For rs828200, the GG genotype (23.7 vs 18.0 %, P<0.001) and G allele (52.7 vs 43.8 %, P<0.001) were common in the breast cancer patients than in the control subjects, respectively. Haplotype analysis showed that C-G (odds ratio (OR)=2.247, 95 % confidence interval (CI) 1.854 similar to 2.722; P<0.001) was associated with increased risk for breast cancer. However, the C-T (OR=0.175, 95% CI 0.110 similar to 0.278; P<0.001) and T-G (OR=0.544; 95 % CI 0.428 similar to 0.692; P<0.001) were associated with decreased risk for breast cancer, respectively. The present study indicated that the RECQL5 genetic polymorphism and haplotypes were associated with breast cancer in a Chinese population.
- 出版日期2014-12
- 单位中国人民解放军陆军军医大学
